Process control of a dropwise additive manufacturing system for pharmaceuticals using polynomial chaos expansion based surrogate model

In this article published in the Journal of Computers and Chemical Engineering, researchers use a hot stage/ polarised microscopy setup (with a THMS600) as part of a process control automation procedure for pharmaceutical formulations.

Read the full paper here (access required).

Preparation of pharmaceutical cocrystal formulations via melt mixing technique: A thermodynamic perspective

In this work, researchers use a hot stage microscopy setup with Linkam’s THMS600 to characterise the thermodynamic properties of cocrystal formulations and gauge their eligibility for large-scale pharmaceutical applications.

Read the full paper here (access required).

“Predicting” Polymorphs of Pharmaceuticals Using Hydrogen Bond Propensities: Probenecid and Its Two Single‐Crystal‐to‐Single‐Crystal Phase Transitions

See how Linkam’s THMS600-PS and Imaging Station are used to screen polymorphs for pharmaceutical applications, using hot stage microscopy to analyse their crystal formation behaviour.

Read the full paper here (access required).