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Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo FIB /SEM Tomography

Researchers use the Linkam CMS196 as part of a Confocal Cryo Fluorescence Microscopy setup to image vitrified biological samples.

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Schertel, Andreas, et al. "Imaging of Vitrified Biological Specimens by Confocal Cryo Fluorescence Microscopy and Cryo FIB/SEM Tomography." European Microscopy Congress 2016: Proceedings. Weinheim, Germany: Wiley‐VCH Verlag GmbH & Co. KGaA, 2016.

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Key composition optimization of meat processed protein source by vacuum freeze-drying technology

This study, using Linkam’s Freeze Drying system FDCS196, shows how the freeze-drying process can be used to preserve meat, discussing the effect of system pressure on the freeze drying efficiency.

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Full Open Access article available via CC BY NC 4.0.

Prickett, Richelle C., et al. "Effect of supercooling and cell volume on intracellular ice formation." Cryobiology 70.2 (2015): 156-163.

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Effect of supercooling and cell volume on intracellular ice formation

Studying the effect of supercooling and cell volume on intracellular ice formation (IIF), using Linkam’s Freeze Drying system FDCS196.

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Full article available per CC BY 4.0.

Prickett, Richelle C., et al. "Effect of supercooling and cell volume on intracellular ice formation." Cryobiology 70.2 (2015): 156-163.

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Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations

Researchers use Linkam’s Freeze Drying system FDCS196 to cryopreserve red blood cells with slow cooling rates prior to storage at -80°C.

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Full article available per CC BY 4.0.

Capicciotti, C.J. et al. Small Molecule Ice Recrystallization Inhibitors Enable Freezing of Human Red Blood Cells with Reduced Glycerol Concentrations. Sci. Rep. 5, 9692; DOI:10.1038/srep09692 (2015).

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Operando micro-spectroscopy on ZSM-5 containing extrudates during the oligomerization of 1-hexene

This article studies the impact of the binder material in industrial catalysts. Using the Linkam TS1500V to perform catalytic reactions at 250 and 300°C, the authors used operando spectrocopy and in situ confocal fluoroscence microscopy to show how different binder materials affect the final material composition.

Hot stage microscopy and its applications in pharmaceutical characterization

This article reviews and summarises the use of hot stage microscopy (HSM) and differential scanning calorimetry (DSC) for pharmaceutical applications.

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Read more about Linkam’s THMS600 for hot stage microscopy and DSC450 for optical differential scanning microscopy.

Full article available per CC BY 4.0.

Kumar, A., Singh, P. & Nanda, A. Hot stage microscopy and its applications in pharmaceutical characterization. Appl. Microsc. 50, 12 (2020). DOI: 10.1186/s42649-020-00032-9