Pharmaceutical Applications
Linkam has been developing sample characterisation solutions to help push the boundaries of science for over 30 years.
Understanding the thermal properties of materials is essential in many areas of the pharmaceutical industry. The precise and accurate control of the temperature of your sample has been further enhanced to enable more detailed characterisation of materials with the introduction of systems such as the new optical DSC, humidity control and lyophilisation systems. Linkam has long worked with the pharmaceutical industry to develop solutions for some of the key problems from drug development and formulation to manufacturing, QA, packaging and storage.
We have solutions for lyophilisation, thermoanalysis, dissolution studies, shelf-life testing and many more.
Linkam systems are compatible with light microscopy and spectroscopy techniques including Raman, FT-IR and X-ray.
Related Products
Published Papers
Application Notes
The FTIR600 stage is used to measure IR spectra at variable temperatures, and transformations between polymorphs followed in situ by heating and cooling the samples in the chamber.
Linkam’s FDCS196 is used by researchers at NIBSC and the University of Strathclyde to predict freeze-drying conditions for liposome-cryoprotectant mixtures (drug delivery systems), using light microscopy with a cryostage.
Researchers from the University of Hertfordshire’s School of Life and Medical Sciences collaborated with Linkam to provide an in-depth analysis into how the optical DSC450 and TASC can be used to characterise drug-polymer-excipient systems for pharmaceutical applications. Read the full case study here.
See how TASC can be used as a rapid and inexpensive screening method during the preformulation stage of solid dispersion based pharmaceutical products.
Polymorphism in pharmaceutical solids has great implications on both the processing and the performance of solid pharmaceutical products. This app note details work from the School of Pharmacy at UCL using TASC with our DSC450 to characterise polymorphic transitions in the pharmaceutical active compound flufenamic acid .
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